Here’s one new study in press on the importance of the unsaturated-to-saturated fat ratio. What they did was reduce saturated fat and add macadamia nuts in order to improve the ratio. At baseline, the ratio was 1.33:1, and after 6 weeks with the diet it was 1.89:1 (very close to the 2:1 Paleolithic ratio).
The result: flow-mediated dilation improved.